Revealing the secrets of secretion

Revealing the Secrets of David Parnas

Those of us in the fast-changing field of computing often dismiss anything written more than five years ago as obsolete. Yet several decades-old papers by David L. Parnas [1, 4, 5, 6, 7, 8] are as timely as those published in recent issues of the top journals. Parnas articulates the timeless software design concepts known as information hiding and abstract interfaces. Most programmers would des...

Revealing water’s secrets: deuterium depleted water

BACKGROUND The anomalous properties of water have been of great interest for generations of scientists. However the impact of small amount of deuterium content which is always present in water has never been explored before. For the first time the fundamental properties of deuterium depleted (light) water at 4°C and 20°C are here presented. RESULTS The obtained results show the important role...

EGFR T790M: revealing the secrets of a gatekeeper

Non-small-cell lung cancers that harbor activating mutations in the EGFR gene represent an important molecularly defined subset of lung cancer. Despite dramatic initial responses with first- and second-generation EGFR-directed tyrosine-kinase inhibitors (TKIs) against these cancers, the development of a dominant and frequent resistance mechanism through a threonine-methionine amino acid substit...

Label-free interaction analysis: revealing the secrets of biomolecular interactions

Unlocking the secrets of chitinase secretion

T o secrete proteins into their extra-cellular environment, gram-negative bacteria must transport them across both the inner and outer cell membranes , as well as the intervening peptido-glycan-rich periplasm. To date, researchers have identifi ed six different pathways for protein secretion (1). Some of them take secretory proteins directly from the cyto-plasm to the cell exterior, whereas oth...